Ruxolitinib molecular weight
WebOverview. Ruxolitinib is an ATP mimic that inhibits all Janus-associated kinase (JAK) family kinases with a preference for JAK-1 and JAK-2 over JAK-3 and TYK2 with IC₅₀ values of … WebSynonym: INCB018424 CAS number: 941678-49-5 Formula: C 17 H 18 N 6 Molecular weight: 306.37 Solubility: 10 mg/ml in DMSO Quality control: Purity ≥97% (UHPLC) Inhibitory …
Ruxolitinib molecular weight
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WebFeb 18, 2024 · At the data cutoff (August 30, 2024), 34 patients with myelofibrosis had received ≥ 1 dose of navitoclax plus ruxolitinib. Most patients were male (n = 23, 68%), … WebRuxolitinib is a kinase inhibitor used to treat various types of myelofibrosis, ... Weight Average: 306.365 Monoisotopic: 306.159294606 Chemical Formula C 17 H 18 N 6 Synonyms. Ruxolitinib; ... The molecular pathogenesis of myeloproliferative neoplasms is not fully understood; ...
WebRuxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through … WebApr 7, 2013 · The molecular weight of INCB018424(Ruxolitinib) is available in molecular weight page of INCB018424(Ruxolitinib), which is calculated as the sum of the atomic masses of each constituent element multiplied by the number of atoms of that element. Chemical formula of INCB018424(Ruxolitinib) The chemical ...
WebTrade name: Ruxolitinib (phosphate) (Contd. from page 4) 53.1.21 9 Physical and chemical properties · Information on basic physical and chemical properties · General Information · Appearance: Form: Solid Color: Not determined. · Odor: Characteristic · Structural Formula C17H18N6 • H3PO4 · Molecular Weight 404.4 g/mol · Odor threshold ... WebMolecular Weight: 306.4 g/mol: Purity >98%: Molecular Formula: C 17 H 18 N 6: CAS: 941678-49-5: Solubility: Soluble in DMSO at 28 mg/ml or ethanol at 15 mg/ml with slight …
WebCat# B2631 Ruxolitinib phosphate SDS DATE: Nov 25, 2024 PAGE 1 OF 3 SECTION 1: PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Ruxolitinib phosphate ... Components CAS Number EC-No. Molecular Weight Chemical Formula Concentration Ruxolitinib phosphate 1092939 -17 7 -- 404.37 C₁₇H₂₁N₆O₄P 100% SECTION 4: FIRST AID …
WebTrade name:Ruxolitinib (Contd. from page 4) 53.0 · Eye protection: _R Tightly sealed goggles * 9 Physical and chemical properties · Information on basic physical and chemical properties · General Information · Appearance: Form: Crystalline Color: Not determined. · Odor: Characteristic · Structural Formula C17H18N6 · Molecular Weight 306. ... itr 1 ay 2022-23 excelWebRuxolitinib sulfate (INCB018424 sulfate) is a potent, selective JAK1/2 inhibitor with IC 50 s of 3.3 nM/2.8 nM. Ruxolitinib sulfate shows > 130-fold selectivity for JAK1/2 versus JAK3. itr 1 and 4WebFeb 9, 2024 · Jakafi (Ruxolitinib) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health … nemd architectsWebApr 24, 2024 · In addition, we investigated the molecular effects of ruxolitinib on Ph-like ALL by combining mass spectrometry phosphoproteomics with gene expression analysis. nemd architects riWebApr 18, 2024 · Ruxolitinib (INCB18424) has a molecular weight of 306.4 g/mol. Its chemical name is (R)-3-(4-(7H-pyrrolo[2,3d-]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3 … nemc washington dcWebMay 31, 2012 · Ruxolitinib [ (R)-3- (4- (7H-pyrrolo [2,3-d]pyrimidin-4-yl)- 1 H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate] is a potent JAK1 and JAK2 inhibitor with an IC 50 of 3.3 and 2.8 nm, respectively. Ruxolitinib exerts its anti-JAK activity by competitive inhibition of the ATP-binding catalytic site of the kinase domain. nemd architects providence riWebJan 10, 2024 · Ruxolitinib phosphate is a Janus kinase inhibitor with the chemical name (R)-3-(4-(7 H-pyrrolo[2,3-d]pyrimidin-4-yl)-1 H-pyrazol-1-yl)-3-cyclopentylpropanenitrile … itr 1998