2024 Klf5 is required

Klf5 is required

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August undefined, 2024

WebAug 15, 2008 · Our results demonstrate that Klf5 is an essential factor of the core regulatory network that maintains ESCs in the undifferentiated state. Klf5 KD does not modify levels … WebFeb 21, 2024 · We thus propose that acetylation of Klf5 is required for a prostate to maintain a pool of basal progenitors and a balanced proliferation and differentiation of such cells. Without Klf5 acetylation, excess basal cells unnecessarily differentiate into luminal cells, which exhausts the pool of basal progenitor cells, causes excess luminal cells ...

Severe liver disease resembling PSC in mice with K5-Cre mediated ...

WebSep 1, 2008 · KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory epithelium that is required for lung function after ... WebApr 11, 2024 · SPI1, HIF1A, STAT1, KLF5, RUNX1, MBD1, SP1, and WT1 may be involved in the regulatory mechanisms of DN development. Our study may provide a potential biomarker or therapeutic locus for the study of DN. ... involved in the progression of DN is required to explore more DN-related biomarkers and improve their relevant clinical evidence, thus ... powder paint in tub black 4kg price

Repurposing of KLF5 activates a cell cycle signature during the ...

WebKLF5 is a basic transcription factor necessary for cell proliferation in epithelial homeostasis. For example, it is highly expressed in proliferating epithelial cells including immortal but untransformed epithelial cell lines as well as proliferating primary cultures of epithelial cells, which mostly represent progenitor cells ( 18 , 19 , 20 ). WebDec 15, 2024 · These data support that KLF5 is required for ADM and oncogenic KRAS-induced PanIN formation. Ndrg2 is a gene of interest detected by the RNA sequencing and validated by qRT-PCR and Western blot, and it is up-regulated in the Klf5-deleted mice 2 days after cerulein-induced pancreatitis . NDRG2 is a member of a family of alpha/beta … towcester crematorium

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Krüpple-Like Factor 5 Is Required for Proper ... - ResearchGate

WebOct 1, 2011 · In the present study, we demonstrate that KLF5 is required for normal maturation of the murine bladder urothelium and suggest that Grhl3 and Pparγ are candidate transcriptional downstream targets that mediate this process. Deletion of Klf5 from the developing bladder urothelium causes prenatal VUR, hydroureter, and hydronephrosis. WebKrüppel-like factor 5 (KLF5) is a zinc-finger transcription factor known to play a pivotal role in the pathogenesis of cardiovascular disease. Here, we show that neonatal heterozygous KLF5 knockout mice exhibit a marked deficiency in white adipose tissue development, suggesting that KLF5 is also required for adipogenesis. towcester dentistWebOct 27, 2024 · KLF5 has been reported as a lineage-survival oncogene whose expression is upregulated in specific cancer types, such as squamous carcinoma (e.g., head and neck cancer, oesophageal cancer) and... powder paint supplier in manila

"WebLiberti et al. show that Klf5 is required to maintain alveolar epithelial type 1 (AT1) versus type 2 (AT2) cell fate during murine lung development. Furthermore, they demonstrate that Klf5 represses adult AT2 cell responsiveness to inflammatory signaling to inhibit proliferation and promote differentiation during lung regeneration after acute injury. " - Klf5 is required

Klf5 is required

Identification of a KLF5-dependent program and drug

WebMar 17, 2024 · Acetylation of KLF5 is required for TGF-β to induce EMT. TGF-β is a master regulator of EMT 45, a process believed to promote tumor metastasis 25. We thus tested whether acetylation of KLF5 is involved in EMT. WebJul 29, 2014 · Rapid replacement of Klf5-mutant crypts with wildtype cells and reduction of stem cell markers suggests further that Klf5 is required for self renewal of intestinal stem cells. Discover the world ...

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WebSep 15, 2015 · Klf5 is required for the expression of Cdx2 in TE cells, while it activates pluripotency gene expression in ESCs. How the transcriptional activity and downstream targets of Klf5 is regulated in these two distinct cell types, remains elusive. Webcell-cell signaling via exosome. positive regulation of pri-miRNA transcription by RNA polymerase II. regulation of gene expression. skeletal muscle satellite cell differentiation. …

WebKLF5 is a DNA-binding transcriptional regulator, and contains three independent C 2 H 2 zinc fingers. 11 KLF5 is expressed in multiple human tissues including small intestine, colon, … WebOct 1, 2011 · KLF5 is required for stratification and terminal differentiation of urothelial cells. Defects in urothelial maturation induces hydronephrosis. KLF5 is not required for maturation of the bladder neck and urethral epithelium. Grhl3 and Pparγ are candidate targets of …

WebSep 3, 2024 · Crucially, when the cell growth genes regulated by KLF5 are activated, patients have lower survival rates. Further work is now required to examine whether this finding could help to identify patients who are most at risk from developing cancer.

WebAug 1, 2008 · In the present study, we generated a model for conditional deletion of Klf5, demonstrating that KLF5 is required for perinatal lung maturation and the expression of many genes crucial for lung function at birth, and that it regulates important but diverse signaling networks that influence lung morphogenesis and maturation. towcester developmentWebAbstract Krüpple-like factor 5 (KLF5) is required for the development of the embryo and multiple organs, such as the lung and intestine. KLF5 plays a pro-proliferative and … powder paint spraying coating lineWebThese results indicate that Klf5 is necessary to maintain adult intestinal crypt proliferation and proper cellular differentiation. Rapid replacement of Klf5-mutant crypts with wildtype … powder paints ukWebMar 17, 2024 · These findings indicate that while KLF5 is indispensable for tumor formation, acetylation renders KLF5 less potent in tumor growth but able to maintain a mesenchymal … powder paint rackingWebFeb 21, 2024 · Here we report that, in human and mouse prostates, Klf5 is expressed in both basal and luminal cells, with basal cells preferentially expressing acetylated Klf5. Functionally, Klf5 is... powder paints for childrenWebDec 10, 2013 · KLF5 was originally cloned as the Basic transcription element binding protein 2 (BTEB2) gene 4. Prior to the reclassification of KLF family nomenclature KLF5 was known as Intestinal krüppel-like factor ... Treatment with a PPARδ agonist is required for deSUMOylation of KLF5 and subsequent activation of these genes. powder pants for over jeansWebJan 5, 2024 · Androgen deprivation resistance is the final common step of many advanced prostate cancers. Li et al. identified the key promoting role of KLF5, the transcription factor Krüppel-like factor 5, in the androgen-AR signaling of LNCaP and C4-2B prostate cell lines. The authors considered this effect as a potential target to develop new therapeutic ... powder paints for lures